PT-141 and Kisspeptin Research Peptides

Melanocortin and reproductive hormone research

This collection brings together peptides used to study two signalling systems: the central melanocortin pathway and the hormonal axis that controls reproduction. It includes PT-141, Kisspeptin, Melanotan 1 and Melanotan 2. Every product is a lyophilised research material, sold strictly for laboratory use and not for human consumption. The two systems meet in the hypothalamus: melanocortin signalling there is studied for its influence on reproductive behaviour, while kisspeptin neurons control the hormonal side of reproduction, so the two are often studied side by side in reproductive neuroendocrinology.

PT-141 and the melanocortin pathway

PT-141, also known as bremelanotide, is a cyclic heptapeptide derived from Melanotan 2. It acts as an agonist at melanocortin receptors, particularly MC3R and MC4R, which are expressed in the central nervous system. That makes it a research tool for studying melanocortin signalling in the brain, as distinct from the pigmentation pathway studied with the Melanotan peptides through the MC1 receptor. Melanotan 2 binds a broader set of melanocortin receptors, which is why the two compounds are used to answer different research questions.

Kisspeptin and the HPG axis

Kisspeptins are peptides encoded by the KISS1 gene that bind the KISS1 receptor, also called GPR54. They sit at the top of the hypothalamic-pituitary-gonadal (HPG) axis, where they stimulate the release of gonadotropin-releasing hormone (GnRH), and they are central to research on puberty, fertility and reproductive endocrinology. Melanotan 1 and Melanotan 2, synthetic α-MSH analogues, complete the melanocortin side of the collection.

Documentation and delivery

Batches are independently tested by Janoshik for identity and purity. Published reports, with batch numbers you can check on Janoshik's own site, are on our Lab Results page, and certificates for other batches are available on request. Keep vials cold and away from light.

Orders ship from the Netherlands in plain, discreet packaging, usually within 24 hours of payment, and are free over €150. For research use only. You receive a tracking code as soon as the parcel is handed to the carrier, and delivery takes 1–2 working days to the Netherlands and Belgium and 3–8 working days to the rest of Europe.

PT-141 and Kisspeptin research peptides: FAQ

What is PT-141?

PT-141 (bremelanotide) is a cyclic heptapeptide and a metabolite of Melanotan 2. It is a melanocortin receptor agonist, studied mainly for its activity at MC3R and MC4R in the central nervous system.

How is PT-141 different from Melanotan 2?

PT-141 is derived from Melanotan 2 but differs at the C-terminus. In the research literature, PT-141 is studied for central melanocortin signalling, while Melanotan 2 is studied more broadly, including for pigmentation through the MC1 receptor.

What is kisspeptin?

Kisspeptin is the name for the peptides encoded by the KISS1 gene. They activate the KISS1 receptor (GPR54) and regulate GnRH release, which makes them a key subject in reproductive endocrinology research.

Is the packaging discreet?

Yes. Every order is tracked and shipped in plain, discreet packaging, and you receive a tracking code as soon as the parcel is handed to the carrier.

Are these peptides tested?

Yes. Batches are analysed by Janoshik, an independent laboratory. You can see published reports on our Lab Results page and request the certificate for any other batch.

Can these peptides be used by people?

No. They are research materials for in-vitro and laboratory study only. They are not medicines, are not approved for human use, and we do not give dosing or usage advice.